Ana Catarina Costa

(Post-Doc Researcher)* 

Alternative Pages: Google Scholar; Research ID; iBB webpage

Status at iBB - Institute for Bioengineering and Biosciences:

·         Researcher of the Biological Sciences Research Group


  • Graduation in Cell Biology and Biotechnology, Faculty of Science, University of Lisbon, Portugal, 2007

  • Master Student in Cell Biology and Biotechnology, Faculty of Science, University of Lisbon, Portugal, 2007-2008

  • PhD in Biotechnology, Instituto Superior Técnico, University of Lisbon, Portugal, 2014


  • Post-doctoral researcher at Institute for Bioengineering and Biosciences

Research Activities:

  • Mechanisms of antifungal drug resistance in the human pathogen Candida glabrata

  • Microbial physiology and molecular biology

  • Chemogenomics and expression proteomics.


  • Grant at BSRG under the project PTDC/BIO/72108/2006

  • Grant at BSRG under the project PTDC/AMB/64230/2006



Costa, C., Studies on the biodegradation of atrazine in soils contaminated with a commercial formulation containing atrazine and s-metolachlor: scale-up of a bioremediation tool based on Pseudomonas sp. ADP and evaluation of its efficacy, Faculty of Sciences of the Lisbon University, 2008

Book chapters

Cavalheiro M., Costa C., Pais P., Teixeira M.C., "Acquisition of resistance to azole antifungal drugs in Candida species: imidazoles versus triazoles", In: Advances in Medicine and Biology (Leon V. Berhardt, Ed.), Nova Science Publishers, Inc., NY, USA, vol.8, chapter 9, 2016

Costa C., Pais P., Teixeira M.C., "Multidrug resistance in pathogenic yeasts: emphasis on the role of ABC and MFS multidrug transporters", In: The Battle Against Microbial Pathogens: Basic Science, Technological Advances and Educational Programs (A. Méndez-Vilas, Ed.), Formatex, Badajoz, Spain, p. 947-954, 2015.

Viegas, C.A., Chelinho, S., Moreira-Santos, M., Costa, C., Gil, F.N., Silva, C., Lima, D., Ribeiro, R., Sousa, J.P., Fialho, A.M., "Bioremediation of soils contaminated with atrazine and other s-triazine herbicides: current state and prospects", In: Advances in Environmental Research (Columbus F., Ed), 6, Nova Science Publishers, Inc., NY, USA, 2010.

Papers in International Journals

Monteiro, P.T., Pais, P., Costa, C., Manna, S., Sá-Correia, I., Teixeira, M.C., 2017, "The PathoYeastract database: an information system for the analysis of gene and genomic transcription regulation in pathogenic yeasts", Nucleic Acids Research, 45(D1):D597-D603, 2017.

Pais, P., Pires, C., Costa, C., Okamoto, M., Chibana, H., Teixeira, M.C., “Membrane proteomics analysis of the Candida glabrata response to 5-flucytosine: unveiling the role and regulation of the drug efflux transporters CgFlr1 and CgFlr2”, Frontiers in Microbiology, 7:2045, 2016.

Santos, R., Costa, C., Mil-Homens, D., Romão, D., de Carvalho, C.C.R., Pais, P., Mira, N.P., Fialho, A.M., Teixeira, M.C.,  The multidrug resistance transporters CgTpo1_1 and CgTpo1_2 play a role in virulence and biofilm formation in the human pathogen Candida glabrata", Cellular Microbiology, doi: 10.1111/cmi.12686.

Pais, P., Costa, C., Cavalheiro, M., Romão, D., Teixeira, M.C., "Transcriptional control of drug resistance, virulence and immune system evasion in pathogenic fungi: a cross-species comparison", Frontiers in Cellular and Infection Microbiology, 6: 131, 2016.

Costa, C., Ribeiro, J., Miranda, I.M., Silva-Dias, A.I., Cavalheiro, M., Costa-de-Oliveira, S., Rodrigues, A.G., Teixeira, M.C., "Clotrimazole drug resistance in Candida glabrata clinical isolates correlates with increased expression of the drug:H+ antiporters CgAqr1, CgTpo1_1, CgTpo3 and CgQdr2", Frontiers in Microbiology, 7:256, 2016.

Pais, P., Costa, C., Pires, C., Shimizu, K., Chibana, H., Teixeira, M.C., “Membrane proteome-wide response to the antifungal drug clotrimazole in Candida glabrata: role of the transcription factor CgPdr1 and the Drug:H+ Antiporters CgTpo1_1 and CgTpo1_2”, Molecular and Cellular Proteomics, 15(1):57-72, 2016.

Costa, C., Ponte, A., Pais, P., Santos, R., Cavalheiro, M., Takashi, Y., Chibana, H., Teixeira, M.C., "New mechanisms of flucytosine resistance in C. glabrata unveiled by a chemogenomics analysis in S. cerevisiae", PLoS ONE, 10(8):e0135110, 2015.

Costa, C., Dias, P.J., Sá-Correia, I., Teixeira, M.C., "MFS multidrug transporters in pathogenic fungi: do they have real clinical impact?", Frontiers in Physiology, 5:197, 2014.

Costa, C., Nunes, J., Henriques, A., Mira, N.P., Nakayama, H., Chibana, H., Teixeira, M.C., The Candida glabrata drug:H+ antiporter CgTpo3 (ORF CAGL0I10384g): role in azole drug resistance and polyamine homeostasis, Journal of Antimicrobial Chemotherapy, 69:1767-76, 2014.

Teixeira, M.C., Monteiro, P.T., Guerreiro, J.F., Gonçalves, J.P., Mira, N.P., dos Santos, S.C., Cabrito, T., Palma, M., Costa, C., Francisco, A.P., Madeira, S.C., Oliveira, A.L., Freitas, A.T., Sá-Correia, I., "The YEASTRACT database: an upgraded information system for the analysis of gene and genomic transcription regulation in Saccharomyces cerevisiae", Nucleic Acids Research, 42: D161-D166, 2014.

Costa, C., Pires, C., Cabrito, T.R., Renaudin, A., Ohno, M., Chibana, H., Sá-Correia, I., Teixeira, M.C., "Candida glabrata drug:H+ antiporter CgQdr2 (ORF CAGL0G08624g) confers imidazole drug resistance, being activated by the CgPdr1 transcription factor", Antimicrobial Agents and Chemotherapy, 57(7):3159-67, 2013.

Costa, C., Henriques, A.S., Pires, C., Nunes, J., Ohno, M., Chibana, H., Sá-Correia, I., Teixeira, M.C., The dual role of Candida glabrata Drug:H+ Antiporter CgAqr1 (ORF CAGL0J09944g) in antifungal drug and acetic acid resistance, Frontiers in Microbiology, 4:170, 2013.

Chelinho, S., Moreira-Santos, M., Silva, C., Costa, C., Viana, P., Viegas, C.A., Fialho, A.M., Ribeiro, R., Sousa, J.P., Semi-field testing of a bioremediation tool for atrazine contaminated soils: evaluating the efficacy on soil and aquatic compartments. Environmental Toxicology and Chemistry, 31(7):1564-72, 2012.

Viegas, C.A., Costa, C., André, S., Viana, P., Ribeiro, R., Moreira-Santos, M., 2012. Does S-metolachlor affect the performance of Pseudomonas sp. strain ADP as bioaugmentation bacterium for atrazine-contaminated soils? PLoS ONE 7(5): e37140, 2012

Lima, D., Viana, P., André, S., Chelinho, S., Costa, C., Ribeiro, R., Sousa, J.P., Fialho, A.M., Viegas, C.A., Evaluating a bioremediation tool for atrazine contaminated soils in open soil microcosms: The effectiveness of bioaugmentation and biostimulation approaches. Chemosphere, 74, 187-192, 2009